First in Human Study of AZD9592 in solid tumors - EGRET

Exclusion Criteria

• • History of (non-infectious) ILD/pneumonitis that required steroids, has current ILD/pneumonitis, or where suspected ILD/pneumonitis cannot be ruled out by imaging at screening.
• • Spinal cord compression or a history of leptomeningeal carcinomatosis.
• • Active infection including tuberculosis and HBV, HCV or HIV
• • Brain metastases unless treated (prior treatment required only for Module 1), asymptomatic, stable, and not requiring continuous corticosteroids at a dose of > 10 mg prednisone/day or equivalent for at least 4 weeks prior to start of study treatment.
• • Participants with cardiac comorbidities as defined in the study protocol